Inhibition of sickling in erythrocytes by amino acids.
نویسنده
چکیده
Sickling of erythrocytes was rapidly and quantitatively inhibited at room temperature by 3.8 mM homoserine, asparagine, and glutamine but by no other amino acid.
منابع مشابه
Intraerythrocytic crystalloid bodies in cats.
SEVERAL HEMOGLOBINOPATHIES of man are known to produce striking morphologic changes in erythrocytes. In vivo sickling, occurring under low oxygen tension, is well documented in hemoglobin 5 (1-lb S) disease. Osmotic dehydration produced by incubation in hypertonic salt solutions fosters sickling in these cells.’ This phenomenon is explained on the basis of a single amino acid substitution, vali...
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A B S T R A C T Although pyridoxal phosphate is known to inhibit gelation of purified hemoglobin S, antisickling activity has never been demonstrated for intact erythrocytes. We incubated washed erythrocytes at 370C either in buffer alone, or with added pyridoxal phosphate or pyridoxal, washed these cells, suspended them in untreated buffer, and compared the percent modified hemoglobin, the oxy...
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عنوان ژورنال:
- Blood
دوره 45 1 شماره
صفحات -
تاریخ انتشار 1975